Although several studies have shown an association between GATA3 and ER signaling pathway (2, 26, 27), the observed preservation of GATA3 expression in primary triple-negative breast cancer samples and metastatic tissues of luminal cancers in the absence of ER expression suggests dissociation of GATA3 from ER signaling in at least some cases of breast cancer (25). This evidence concerns the gene ESR1 and breast cancer.