When released into tumor microenvironment, ATP acts on P2X7 purinergic receptors and triggers the NOD-like receptor family, pyrin domain containing-3 protein (NLRP3), allowing for the secretion of interleukin-1beta (IL-1β) then primes IFNγ-producing tumor antigen-specific CD8+ T cell in mice (49). The gene discussed is CD8A; the disease is neoplasm.