Tumor-infiltrating leucocytes (TILs) isolated from locally advanced hepatocellular carcinoma after Yttrium-90 (Y90)-radioembolization (RE) exhibited signs of local immune activation including higher expression of granzyme B (GB) and infiltration of CD8+ T cells, CD56+ NK cells and CD8+CD56+ NKT cells. This evidence concerns the gene CD8A and hepatocellular carcinoma.