ASXL1 and acute myeloid leukemia: A preliminary report in a mouse model demonstrated that induction of ASXL1 mutation in hematopoietic stem and progenitor cells induced hematopoietic dysfunction followed by an increase in mitochondrial activity and ROS production (75), which might indicate for a potential role of metabolic dysregulation in pathogenesis of ASXL1-mutated AML.