Besides, the gene expression analysis from the TCGA database showed that HOIL-1 was positively correlated with ERα target gene expression including GREB1 and TFF1 in breast tumors (P <0.01, R = 0.17; P = 0.008, R = 0.08 respectively) (Figures 1F, G). Here, TFF1 is linked to breast neoplasm.