The top five genes with a high degree of difference were GNAS, CDKNA1, STAT1, STAT5A and MAP2K1. Enrichment with KEGG pathways revealed that the top five highest enrichment pathways were the following: pathway in cancer, hepatitis, MAPK signaling pathway, breast cancer and PI3K-Akt signaling pathway. The gene discussed is AKT1; the disease is hepatitis A virus infection.