To further explore the mechanism of differential expression of ITGA3 in breast cancer and normal breast tissue, we used the cBio-Portal tool to analyze the genome of ITGA3. We selected the TCGA (Firehose Legacy) of breast invasive carcinoma for analysis, and in Figure 6A, ITGA3 was altered in 113 of 960 (12%) BRCA patients, including mutation in 1 case (0.1%), amplification (AMP) in 62 cases (6.46%), deep deletion in one case (0.1%), mRNA high in 13 cases (1.35), mRNA low in 23 cases (2.4%), and multiple alterations in 13 cases (1.35%). The gene discussed is ITGA3; the disease is invasive breast carcinoma.