These results showed that the downregulation of RSK and p70S6K could mimic the effects of miR-486-5p in NSCLC cells, indicating that the function of miR-486-5p on NSCLC cell phenotype was exerted at least partly via downregulation of RSK and p70S6K. This evidence concerns the gene RPS6KA1 and non-small cell lung carcinoma.