These results showed that the downregulation of RSK and p70S6K could mimic the effects of miR-486-5p in NSCLC cells, indicating that the function of miR-486-5p on NSCLC cell phenotype was exerted at least partly via downregulation of RSK and p70S6K. The gene discussed is RPS6KB1; the disease is non-small cell lung carcinoma.