To further study the effect of RSK and p70S6K on NSCLC, RSK and p70S6K siRNAs (siRSK 1-3 and sip70S6K 1-3) were transfected into A549 and H1299 cells, resulting in a significant reduction of mRNA (Figure S4). Here, RPS6KB1 is linked to non-small cell lung carcinoma.