Also, RSK and p70S6K expression showed to be negatively correlated with that of miR-486-5p in the NSCLC tissue samples (Figure S3), especially in the LUAD samples (Figures 3H, I), with their expression being significantly upregulated in most of NSCLC cell lines (Figures 3N, S). The gene discussed is RPS6KA1; the disease is non-small cell lung carcinoma.