After observing the interaction between XBP1 and IGFBP3, we then investigated whether XBP1 regulates NSCLC cells invasion and metastasis by regulating IGFBP3, we transfected IGFBP3 siRNA into A549 cells for further experiments (Figure 5E). This evidence concerns the gene IGFBP3 and non-small cell lung carcinoma.