IGFBP3 and lung adenocarcinoma: In addition, it has been reported that up-regulated of IGFBP3 promoted A549 cell migration and invasion, and further analysis showed overexpression of IGFBP3 might mediate brain metastasis in lung adenocarcinoma, these data indicated IGFBP3 was associated with tumorigenesis and development in lung adenocarcinoma (30).