And then, we selected 7 cancer-related genes (DNAJB2, USP47, FKBP2, SEC24D, PYCR1,MANF and IGFBP3) in 80 upregulated genes (Unique Peptides>2 Σ# PSMs>10) and evaluated the expression of the selected 7 genes in NSCLC by Oncomine (https://www.oncomine.org/) (Supplementary Figure S1), we found that only IGFBP3 was highly expressed in NSCLC and the expression of the selected 7 genes in NSCLC tumor tissues (Figure 5A). This evidence concerns the gene IGFBP3 and cancer.