With the aim to identify new diagnostic and therapeutic biomarkers for colon cancer, we here performed a bioinformatics analysis and found that the PPFIA4 (protein tyrosine phosphatase receptor type F polypeptide interacting protein α-4) gene, which encodes for the liprin-alpha-4 protein (7), demonstrated significant differential expression in colon cancer. Here, PPFIA4 is linked to malignant colon neoplasm.