As shown in Figures, antigen processing and presentation, B cell receptor signaling pathway, chemokine signaling pathway, cytokine cytokine receptor interaction, natural killer cell mediated cytotoxicity, primary immunodeficiency, T cell receptor signaling pathway, and Toll-like receptor signaling pathway were enriched in the SERPINE1 high expression group from the TCGA cohort (Figure 6E and Supplementary Table 4). Here, SERPINE1 is linked to inborn error of immunity.