According to our prediction, the expression of nine key genes related to the prognosis of pancreatic cancer (MMP14, ITGA2, THBS2, COL1A1, COL3A1, COL11A1, COL6A3, COL12A1 and COL5A2) was upregulated. This evidence concerns the gene COL5A2 and familial pancreatic carcinoma.