According to our prediction, the expression of nine key genes related to the prognosis of pancreatic cancer (MMP14, ITGA2, THBS2, COL1A1, COL3A1, COL11A1, COL6A3, COL12A1 and COL5A2) was upregulated. The gene discussed is COL12A1; the disease is familial pancreatic carcinoma.