Next, we selected several EZH2 or LSD1 potential targets (P15, P21, KLF2, PTEN, KLF2, LATS2, RND3, and NKD2) with tumor-suppressive role, and hypothesized that some of which might be associated with LINC00665-mediated carcinogenicity. This evidence concerns the gene RND3 and neoplasm.