Interestingly, HEPH/FPN1 double-labeling experiments showed that both ferroxidase and its functionally-coupled iron permease were both poorly expressed in most of the cancer cells of the analysed LUAD and LUSC specimens, while their expression was still maintained in nesting arrangement of cancer cells having a characteristic epithelial differentiation (Supplemental Figure 2). The gene discussed is SLC40A1; the disease is cancer.