Previous studies have suggested that ARID5A can stabilize the mRNAs encoding the IL-6 and Stat3 genes (30), while IL-6 and/or STAT3 can modulate p53 expression in gene transcription and protein degradation (39, 40), suggesting that ARID5A may be associated with the P53 signaling pathway and JAK-STAT signaling pathway in tumor growth and development. This evidence concerns the gene STAT3 and neoplasm.