IL6 and liver cancer: According to previous studies, lncRNA-activated by TGF-β (lncRNA-ATB) has the ability to upregulate ZEB1 and ZEB2, and predispose HCC patients to metastases, while lncRNA downregulated in liver cancer stem cells (lnc-DILC) functions to suppress the expression of inflammatory cytokine IL−6, which in turns inhibits IL6-STAT3 autocrine signaling and suppress LCSC propagation (7, 8).