To further verify the above results, we used TLR3 agonist Poly(I:C) to treat lung cancer cells (A549) and found that the expressions of MYD88, Caspase 8, BIRC3 and PIK3R1 were in line with the expression of TLR3 (Figures 7B, C). Here, CASP8 is linked to lung carcinoma.