To our knowledge, despite these preliminary expression pattern studies of AR in GBM and its known functions/signaling in prostate cancer, there has been no reported studies in confirming the therapeutic role of targeting AR in GBM in brain although a previous study from Zalcman et al. and a very recent report from Werner et al. showed promising results in flank implant models (30, 31). Here, AR is linked to Familial prostate cancer.