HK2 and colon adenocarcinoma: According to the GEPIA2 web tool (http://gepia.cancer-pku.cn/) based on the TCGA database, the NRF2 (NFE2L2) gene and genes of key enzymes mediating the Warburg effect (LDHA, PGK1, and HK2) are positively correlated in colon adenocarcinoma (COAD) patients (Figure 6C).