Further support of the role of inflammation and PGE2 in tumour progression comes from an OSCC study showing that fibroblasts (an important stromal cell component of the tumour microenvironment) enhances PGE2 secretion and upregulates COX-2 and mPGES-1 leading to increased angiogenesis and tumour cell migration and proliferation (80). The gene discussed is PTGES; the disease is neoplasm.