Atopy, a genetic predisposition to produce an excess amount of immunoglobulin E (IgE) antibodies when exposed to allergens is nearly a universal finding in children with asthma [5,6]. Allergic sensitization is a hypersensitivity reaction to a particular antigen, which can be assessed by in-vivo demonstration of bound IgE and mast cell degranulation by skin prick testing (SPT) or in-vitro tests to detect the production of free IgE to a specific allergen (sIgE) [7]. Allergic sensitization using SPT is not a routine practice and sensitization data on childhood asthma in India are scarce [8]. This evidence concerns the gene IGHE and asthma.