TGFB1 and neoplasm: In another attempt, an immunocytokine,NHS-muIL12, consisting of two molecules of IL-12 combined with NHS76, a tumor necrosis-targeting human IgG1, reduced the myeloid derived suppressor cells, tumor related TGF-β and macrophages in tumour microenvironment resulting in reactivation of Th cells to activate immune response against MB49luc bladder tumors in mice [108].