LAG3 and urinary bladder cancer: Bladder cancer cells express immune ligands such as programmed death-1 receptor (PD-1), PD-L1, lymphocyte-activation gene-3 (LAG-3), TIM-3 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) on its surface to evade immunological response and checkpoints [100, 104].