APP and Alzheimer disease: Recently, one comprehensive paper found that restoration of neuronal mitophagy by NAD+ precursor supplementation (NMN, UA and AC), can reduce insoluble Aβ1-42 and Aβ1-40 levels and against cognitive impairment in both C. elegans and APP/PS1 AD mouse model through microglial phagocytosis and suppression of neuroinflammation.