Therefore, based on the reported CDD human cases (most of them are under 18 years of age; [7]), we decided to analyze the phenotype of young/adult Cdkl5 KO mice (2-4 months in the mouse corresponding to 6-15 years in humans; [40]) in comparison with middle-aged Cdkl5 KO mice (12-14 months in the mouse corresponding to 40-45 years in humans; [40]). Here, CDKL5 is linked to craniodiaphyseal dysplasia.