Additionally, atheroprone flow induces the nod-like receptor protein-3 (NLRP3) inflammasome in the endothelium through SREBP2, and the activated NLRP3 inflammasome synergizes with hyperlipidemia to increase atherosclerosis in apolipoprotein E-/- (ApoE-/-) mice [24]. The gene discussed is APOE; the disease is hyperlipidemia.