18 This can offer a novel cancer therapeutic strategy that avoids direct interactions with the MYC protein which has a short half-life and is difficult to target with common ligand–protein interactions.19 Another example of G4s associated with prevalent oncogenes is the c-KIT and its dysregulation has been reported in the development of several types of cancers and is the main cause of gastrointestinal cancer.20 There are two sequences in the c-KIT promoter region capable of folding into G4s, the c-KIT G4 and, c-KIT1 G4. Here, KIT is linked to cancer.