Han et al. reported an aza-bodipy dye for the labelling of tumours that is internalized through cell surface binding to a tumour membrane-targeting ligand peptide (pHLIP).28 Recently, Urano et al. developed a Si-rhodamine fluorescence probe for pH mapping in live cells.29 These researchers estimated apparent pH fluctuations in cellular organelle through time-lapse imaging using transferrin tagged Si-rhodamine. This evidence concerns the gene TF and neoplasm.