Up-regulation of several members of the intrinsic pathway of apoptosis (Casp-9, Bax) and p53 as targets of under-expressed oncomiRs and down-regulation of Bcl-2 as the target of over-expressed tumor suppressive-miRs in PANC-1 cells treated with SPNs suggested the efficiency of silybin in cell growth inhibition via several mechanisms. The gene discussed is TP53; the disease is neoplasm.