In addition, the IL-1β level as the marker of activation of NLRP3 inflammasome had a direct correlation with MMP9 and an inverse relationship with Ecadherin in the present study confirming that activation of NLRP3 inflammasome and initiation of inflammation via production of IL-1β in colorectal cancer is directly associated with the evoking of epithelial to the mesenchymal transition process. This evidence concerns the gene CDH1 and colorectal cancer.