CDH2 and cancer: There also several linelines of in vivo and in vitro evidence confirming that loss of or reduced E-cadherin expression is associated with local lymph node metastasis (27), aggressive phenotypes in colorectal cancer (28), and inasion (29), whereas, metastasis of different cancer types such as colorectal cancer ccompanied with the increased mesenchymal markers including vimentin, N-cadherin, and MMP9 (30).