Hence, we studied the expression patterns of key markers of apoptosis in HER2-positive breast cancer cells under the effect of the cationic PAMAMs (G4NH2 and G6NH2) and lapatinib; we found enhanced expression of the pro-apoptotic markers (Bax, Caspase-3, 8, and 9) in PAMAM-treated cells compared to their control as shown in Fig. 6, Fig. 7. This evidence concerns the gene BAX and breast carcinoma.