Overall, intratracheal injection of Srpx2 siRNA loaded liposomes could block TGF-β signaling pathway and subsequently decelerate the process of FMT, contributing to the protection of mice from BLM-induced lung injury and fibrosis, which provide an available, safe and effective therapeutic approach for IPF. The gene discussed is TGFB1; the disease is idiopathic pulmonary fibrosis.