Recently, several NPs have been reported to elicit tumor microenvironment modulation, such as the macrophage reprogramming by manganese dioxide NPs 17 or by magnetic NPs 18, 19, and the promotion of anti-tumor cytotoxic T cells' function by granzyme B NPs 20, as well as the augmented cytotoxic T cells recruitment to tumor site by antibody-targeted NPs 21. This evidence concerns the gene GZMB and neoplasm.