In addition, the ELISA results showed an increase of IFN-γ secretion upon anti-CD3/anti-CD28 stimulation (Left, Figure 1G) and the lymphocyte-mediated cytotoxicity against cancer cell assay demonstrated an enhanced cancer cell killing effect of CD8+ T cells from Rab37 KO mice (Right, Figure 1G). The gene discussed is CD28; the disease is cancer.