HGF and hepatocellular carcinoma: In this study, by systematically screening the dynamic changes of site-specific N-glycans in three HGF or TGF-β1 treated HCC cell lines, complemented by molecular biology approaches, we provided solid evidences to show that the folate uptake capacity of FOLR1 is enhanced by its increased site-specific core-fucosylation, and therefore links these two stimulation factors into one complete pathway 20.