Based on above results, we concluded that HGF treatment of HCC cells can increase the expression of glycosyltransferase FUT8 to up-regulate the core-fucosylation of N-glycans on glycoproteins, especially FOLR1; core-fucosylation on FOLR1 can then enhance the folate uptake capacity of HCC cells to promote the progression of EMT (Figure 7). This evidence concerns the gene HGF and hepatocellular carcinoma.