HGF and hepatocellular carcinoma: As shown in Figure 4B, S11B, overexpression of FUT8 significantly increased the protein and mRNA expression level of N-cadherin, which is a key marker of EMT, while significantly decreased the protein and mRNA expression of E-cadherin, indicating that up-regulation of FUT8 could trigger the EMT of HCC cell lines, a similar effect as the HGF or TGF-β1 treatment.