SPI1 and leukemia: To further test if the inhibitory effect of Tan I exhibited in malignant hematopoiesis, we used a high concentration of Tan I to treat two previously reported zebrafish leukemia models, c-MYB hyperactive (c-mybhyper) zebrafish 23 and pu.1 hypomorphic (pu.1G242D) zebrafish 24.