These results indicated that EZH2 is required for the maintenance of chemoresistance in PCa cells; (2) EZH2 knockdown in C4-2B-TaxR cells effectively inhibited the phosphorylation of Stat3 at S727, suggesting that EZH2 is required for the activation of Stat3 signaling. Here, EZH2 is linked to posterior cortical atrophy.