This functional connection between p-EZH2(S21) and Stat3 activation was also observed in chemoresistant PCa cells, indicating that EZH2 may have a noncanonical role in the activation of Stat3 signaling and the acquisition of chemoresistance, which is independent of the epigenetic repressor activity of EZH2. The gene discussed is EZH2; the disease is posterior cortical atrophy.