They transduced hNIS into specific PSMA-targeting CAR-T (4P28ζN+) cells, which did not reduce their expression of CAR, and did not interfere with their efficient killing properties against the PSMA-overexpressing prostate cancer cell line PC-LN-PSMA in vitro as well as against tumor-bearing mice in vivo. The gene discussed is FOLH1; the disease is prostate cancer.