We demonstrate that cell-cell adhesion consisting of N-cadherin mediates the collective migration of BM-MSCs to MDA CM, an experimental condition simulating the tumor microenvironment derived by TGF-β-secreting breast tumor cells, but the mechanism(s) by which N-cadherin-dependent cell-cell adhesion mediates the collective migration of BM-MSCs remains unknown. This evidence concerns the gene TGFB1 and breast neoplasm.