SMAD4 and breast neoplasm: In the present study, we demonstrate that the expression of N-cadherin in BM-MSCs increases in a manner dependent on TGF-β canonical signaling (Smad4-dependent manner), and that N-cadherin-dependent cell-cell adhesion is required for the migration of BM-MSCs in vitro in response to TGF-β and breast tumor cells expressing TGF-β.