Thus, dissociation by nerinetide of GluN2B-PSD-95-nNOS ternary complexes formed by PDZ1-2 is neuroprotective in excitotoxicity and ischemia 20-22, 24, conditions that uncouple the PDZ1-2 supramodule from the rest of the protein due to PSD-95 processing. Here, NOS1 is linked to ischemia.