A meta-analysis of 11 studies demonstrated that survivin expression was significantly associated with poor OS (HR=2.28; 95% CI=1.57-3.33; P<0.001) and poor cancer-specific survival (HR=2.08; 95% CI=1.07-4.05; P=0.032) in renal cell carcinoma 53. This evidence concerns the gene BIRC5 and cancer.