Some scholars have also pointed out that 2-methoxy-6-acetyl-7-methyljuglone (MAM) can promote the death of HCT116 and HT29 colon cancer cells, and RIP1/RIP3 complex-induced cytosolic calcium accumulation is a key mediator in MAM-induced necroptosis in human colon cancer cells via mitochondrial ROS production and sustained JNK activation 70. Here, MAPK8 is linked to colonic neoplasm.