They revealed that the Smac mimetic, an inhibitor of apoptosis protein (IAP) antagonist, sensitized CCA cells to low-dose standard chemotherapy, gemcitabine, and induced necroptosis in a RIP1/RIP3/MLKL-dependent manner based on caspase inhibition, but not in non-tumor cholangiocytes 99. The gene discussed is MLKL; the disease is cholangiocarcinoma.