RUNX2 and nasopharyngeal carcinoma: EdU assay and transwell invasion assays revealed that miR-635 inhibitors (or RUNX2 overexpression) reversed the effects of circRANBP17 silencing in NPC cell proliferation and invasion (Fig. 6D-6E), suggesting that increased circRANBP17 reduced miR-635 activity to increase RUNX2 expression, thus promoting NPC cell proliferation and invasion (Fig. 7).