In our exploration, we found out that by combining IDH1 mutation with ATRX mutation, gliomas in the low-risk group could be further divided into three subtypes: LowRisk_IDH1wt, LowRisk_IDH1mut/ATRXmut and LowRisk_IDH1mut/ATRXwt with obvious survival difference (Fig. 4E). Here, IDH1 is linked to central nervous system cancer.