HAVCR2 and neoplasm: As a member of the galectin family, more and more research revealed that Gal-9 is a negative regulator of tumor immune responses by promoting Th1, Th17 and cytotoxic T cells exhaustion, driving the expansion of myeloid-derived suppressor cells and FoxP3+Tregs when interactions with its ligand Tim-3 8, 10, 11.