Our study showed that compared with normal bone marrow samples, the mRNA expression of RhoB, RhoBTB2, RhoF, RhoQ, and RhoU was significantly increased in AML bone marrow samples, while the mRNA expression levels of Rac3, RhoBTB1, RhoBTB3, RhoC, and RhoV was decreased in AML bone marrow. Here, RHOBTB3 is linked to acute myeloid leukemia.