Studies have elucidated that hsa-miR-103 and hsa-miR-107 were involved in Wnt3a/β-catenin/ATF6 signaling pathway and were critical to the progression of colorectal cancer, Alzheimer's disease, breast cancer and cardiac function 33-36. The gene discussed is WNT3A; the disease is early-onset autosomal dominant Alzheimer disease.