Moreover, silencing endogenous NMHC IIA reduced the migration and invasion of the nasopharyngeal cancer cell line in vitro by inhibiting the phosphorylation of EGFR, AKT and ERK, while overexpression of NMHC IIA notably increased cells migration and invasion by enhancing the phosphorylation of EGFR, AKT and ERK. Here, EGFR is linked to nasopharyngeal carcinoma.