Since these pRS-related hub genes (EGFR, INHBA, CFLAR, DAPK2, TSC2, CAPN10, MBTPS2, PEX14, FADD and ST13) show strong heterogeneity in different cells, we speculate that these genes alone can predict cellular composition to reflect the microenvironment of tumor tissues. This evidence concerns the gene TSC2 and neoplasm.