SPRR2B and laryngeal carcinoma: “LIMMA”R package was also used to identify laryngocarcinoma-related circRNAs between laryngeal cancer and normal samples, which were showed in Supplementary Figure 2A. Based on the miRTarBase and miRWalk databases, linkages between pRS-related mRNAs and pRS-related miRNAs are demonstrated in Supplementary Figure 2B. In total, 10 pRS-related mRNAs (COX6B2, EGFR, CD274, LMOD2, CAV1, MB, CREG2, PHYHIP, TNNI1, and SPRR2B) were likely influenced by the down-regulation of hsa-miR-552.