KEGG pathways enrichment analysis of pRS-related pathways revealed the apoptosis-multiple species, autophagy, AMP signaling pathway, intestinal immune network for lgA production, microRNAs in cancer, PD-L1 expression and PD-1 checkpoint pathway, PI3K-Akt signaling pathway and Th17 cell differentiation (Figure 7B). The gene discussed is AKT1; the disease is cancer.