This former research found the gene function could not cooperate with the clinical outcome neither our study nor other studies 20, this may because TIMP2 was not only the target by ncRNA, the function of TIMP2 was overlapped by different genes which have not been found. TIMP3 also involved in DUMT3B/TIMP3/STAT1/FOXO1 pathway in breast cancer, regulated by miR-29c, knocking down of miR-29c could increase TIMP3 protein level but decrease the methylation of TIMP3, which promoted cell migration, invasion and proliferation 30. This evidence concerns the gene FOXO1 and breast carcinoma.