The markers of Naive CD4 T cells in HCC tissues were CD45RA, CD4, and IHC staining results showed that the protein expression level of CD45RA and CD4 was significantly higher in HCC patients with LRP1B mutation than in the wild group (Fig. 6A, 6B), indicating that the infiltration amount of Naive CD4 T cells in the LRP1B mutant group was significantly higher than that in the wild group. The gene discussed is LRP1B; the disease is hepatocellular carcinoma.