Finally, in TCGA and ICGC databases,15 duplicated genes (Fig. 1C), including LRP1B, TP53, TTN, MUC16, AHNAK2, OBSCN, FLG, PCLO, APOB, HMCN1, ADGRV1, USH2A, CSMD3, XIRP2, RYR2, were frequently mutated in HCC patients. Here, XIRP2 is linked to hepatocellular carcinoma.