Among commonly mutated genes, LRP1B, TP53, TTN, MUC16, AHNAK2, OBSCN, FLG, PCLO, HMCN1, USH2A, CSMD3, XIRP2, and RYR2 mutations significantly associated with higher TMB in HCC patients (Fig. 2). The gene discussed is HMCN1; the disease is hepatocellular carcinoma.