Finally, in TCGA and ICGC databases,15 duplicated genes (Fig. 1C), including LRP1B, TP53, TTN, MUC16, AHNAK2, OBSCN, FLG, PCLO, APOB, HMCN1, ADGRV1, USH2A, CSMD3, XIRP2, RYR2, were frequently mutated in HCC patients. This evidence concerns the gene LRP1B and hepatocellular carcinoma.