RYR2 and hepatocellular carcinoma: Finally, in TCGA and ICGC databases,15 duplicated genes (Fig. 1C), including LRP1B, TP53, TTN, MUC16, AHNAK2, OBSCN, FLG, PCLO, APOB, HMCN1, ADGRV1, USH2A, CSMD3, XIRP2, RYR2, were frequently mutated in HCC patients.