Among commonly mutated genes, LRP1B, TP53, TTN, MUC16, AHNAK2, OBSCN, FLG, PCLO, HMCN1, USH2A, CSMD3, XIRP2, and RYR2 mutations significantly associated with higher TMB in HCC patients (Fig. 2). Here, TP53 is linked to hepatocellular carcinoma.