Finally, in TCGA and ICGC databases,15 duplicated genes (Fig. 1C), including LRP1B, TP53, TTN, MUC16, AHNAK2, OBSCN, FLG, PCLO, APOB, HMCN1, ADGRV1, USH2A, CSMD3, XIRP2, RYR2, were frequently mutated in HCC patients. This evidence concerns the gene MUC16 and hepatocellular carcinoma.