The regulated genes by miR-10b were significantly enriched in cell cycle, FoxO signaling pathway, proteoglycans in cancer, microRNAs in cancer, central carbon metabolism in cancer, pancreatic cancer, p53 signaling pathway, Notch signaling pathway, HIF-1 signaling pathway, Focal adhesion, AMPK signaling pathway and Pathways in cancer. This evidence concerns the gene TP53 and familial pancreatic carcinoma.