CSMD1 and esophageal squamous cell carcinoma: In addition, Chen XL et al. found that miR-10b promoted the invasion and metastasis of human gastric cancer cells through inhibiting the expression of CSMD1, causing the activation of the NF-κB pathway while Lu YF et al. suggested up-regulated expression of miR-10b-3p caused by promoter hypomethylation contributed to the progression of esophageal squamous cell carcinoma 38,72.