The study of Dobrzycka B et al. showed that serum VEGF level was significantly increased in patients with serous ovarian cancer (SOC) compared with healthy control group, and higher serum VEGF level was significantly correlated with poor prognosis, and multivariate analysis confirmed that serum VEGF level was an independent risk factor for prognosis 31. The gene discussed is VEGFA; the disease is ovarian serous adenocarcinoma.