MUC16 and neoplasm: In recent years, MSLN as a differentiation antigen has been proved to be overexpressed in malignant pleural mesothelioma, pancreatic cancer, ovarian cancer and other malignant tumors, and may through increased synthesis of cyclinD1 and suppress the degradation and forming MSLN/MUC16 complex pathways involved in tumor cell proliferation, adhesion and transfer process, it is related to transcoelomic spread of ovarian cancer cells 323.