CDK5 and cancer: Additionally, CDK5 expression was also significantly correlated with Karnofsky Performance Status (KPS) (P <0.001), family history of cancer (P = 0.03), and tumor status (P = 0.004) in TCGA cohorts, while no significant differences were observed for KPS (P = 0.231) and IDH1 mutation (P = 0.48) in GSE16011 cohorts (Figure 2E-H).